Low-density lipoprotein receptor-related protein 1 mediates hypoxia-induced very low density lipoprotein-cholesteryl ester uptake and accumulation in cardiomyocytes | Zendy

Roi Cal | Zendy; José Castellano | Zendy; Elena RevueltaLópez | Zendy; Rosa Aledo | Zendy; Montse Barriga | Zendy; Jordi Farré | Zendy; Gemma Vilahur | Zendy; Laura Nasarre | Zendy; Leif HoveMadsen | Zendy; Lina Badimón | Zendy; Vicenta LlorenteCortés | Zendy

Open Access

Low-density lipoprotein receptor-related protein 1 mediates hypoxia-induced very low density lipoprotein-cholesteryl ester uptake and accumulation in cardiomyocytes

Author(s) -

Roi Cal,

José Castellano,

Elena RevueltaLópez,

Rosa Aledo,

Montse Barriga,

Jordi Farré,

Gemma Vilahur,

Laura Nasarre,

Leif HoveMadsen,

Lina Badimón,

Vicenta LlorenteCortés

Publication year - 2012

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvs136

Subject(s) - chemistry , hypoxia (environmental) , low density lipoprotein , low density lipoprotein receptor related protein 8 , lipoprotein , cholesteryl ester , ldl receptor , endocrinology , medicine , cholesterylester transfer protein , very low density lipoprotein , microbiology and biotechnology , biochemistry , biology , cholesterol , oxygen , organic chemistry

The myocardium accumulates intracellular lipids under ischaemic conditions, and myocardial fat deposition is closely associated with cardiac dysfunction. Our aims were to analyse the effect of hypoxia on low-density lipoprotein receptor-related protein 1 (LRP1) expression in neonatal rat ventricular myocytes (NRVM) and cardiac-derived HL-1 cells and the molecular mechanisms involved in this effect, to determine the role of LRP1 in the very low density lipoprotein (VLDL) uptake by hypoxic cardiomyocytes, and to study the effect of hypoxia on lipoprotein receptor expression and myocardial lipid profile in an in vivo porcine experimental model of acute myocardial infarction.

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