The SDF-1/CXCR4 axis in stem cell preconditioning | Zendy

Chiara Cencioni | Zendy; M. C. Capogrossi | Zendy; Monica Napolitano | Zendy

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The SDF-1/CXCR4 axis in stem cell preconditioning

Author(s) -

Chiara Cencioni,

M. C. Capogrossi,

Monica Napolitano

Publication year - 2012

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvs132

Subject(s) - cxc chemokine receptors , stromal cell , cxcr4 , progenitor cell , stromal cell derived factor 1 , chemokine receptor , chemokine , ischemia , stem cell , microbiology and biotechnology , endothelial progenitor cell , medicine , revascularization , receptor , pharmacology , biology , cancer research , myocardial infarction

We review the pivotal role of the stromal derived factor (SDF)-1 chemokine in tissue ischaemia and how it orchestrates the rapid revascularization of injured, ischaemic, and regenerating tissues via the CXC chemokine receptors CXCR4 and CXCR7. Furthermore, we discuss the effects of preconditioning (PC), which is a well-known protective phenomenon for tissue ischaemia. The positive effect of both hypoxic and acidic PC on progenitor cell therapeutic potential is reviewed, while stressing the role of the SDF-1/CXCR4 axis in this process.

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