Effects of peroxisome proliferator-activated receptor-γ agonists on the generation of microparticles by monocytes/macrophages | Zendy

Tommaso Neri | Zendy; Cinzia Cordazzo | Zendy; Yuri Carmazzi | Zendy; Silvia Petrini | Zendy; Cristina Balìa | Zendy; Fabio Stefanelli | Zendy; Angela Amoruso | Zendy; Sandra Brunelleschi | Zendy; Maria Cristina Breschi | Zendy; Roberto Pedrinelli | Zendy; Pierluigi Paggiaro | Zendy; Alessandro Celi | Zendy

Open Access

Effects of peroxisome proliferator-activated receptor-γ agonists on the generation of microparticles by monocytes/macrophages

Author(s) -

Tommaso Neri,

Cinzia Cordazzo,

Yuri Carmazzi,

Silvia Petrini,

Cristina Balìa,

Fabio Stefanelli,

Angela Amoruso,

Sandra Brunelleschi,

Maria Cristina Breschi,

Roberto Pedrinelli,

Pierluigi Paggiaro,

Alessandro Celi

Publication year - 2012

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvs125

Subject(s) - microparticle , tissue factor , chemistry , annexin , rosiglitazone , peroxisome proliferator activated receptor , phosphatidylserine , cd36 , pharmacology , receptor , microbiology and biotechnology , endocrinology , medicine , biology , apoptosis , biochemistry , coagulation , phospholipid , membrane , astrobiology

Microparticles are membrane vesicles shed by cells upon activation and/or apoptosis. Microparticles are involved in several processes, including blood coagulation and thrombosis. In addition to their role in the regulation of lipid metabolism, peroxisome proliferator-activated receptor-γ (PPAR-γ) agonists exert other effects, both dependent on and independent of PPAR-γ activation. Some PPAR-γ agonists have been linked to an increased risk of thrombotic diseases. We aimed to investigate the potential role of PPAR-γ agonists on the generation of procoagulant microparticles by human monocytes/macrophages.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research