Angiopoietin-1 mediates inhibition of hypertension-induced release of angiopoietin-2 from endothelial cells | Zendy

Thomas Korff | Zendy; E Ernst | Zendy; R. Nobiling | Zendy; Anja Feldner | Zendy; Yvonne Reiss | Zendy; Karl H. Plate | Zendy; Ulrike Fiedler | Zendy; Hellmut G. Augustin | Zendy; Markus Hecker | Zendy

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Angiopoietin-1 mediates inhibition of hypertension-induced release of angiopoietin-2 from endothelial cells

Author(s) -

Thomas Korff,

E Ernst,

R. Nobiling,

Anja Feldner,

Yvonne Reiss,

Karl H. Plate,

Ulrike Fiedler,

Hellmut G. Augustin,

Markus Hecker

Publication year - 2012

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvs124

Subject(s) - microbiology and biotechnology , endothelial stem cell , calcium in biology , intracellular , endothelium , calcium , autocrine signalling , endocrinology , angiopoietin , medicine , stimulation , receptor , biology , chemistry , in vitro , biochemistry , vascular endothelial growth factor , vegf receptors

Adequate endothelial cell stimulation is a prerequisite for the adaptive remodelling of macro- and microvessels. A pivotal autocrine mechanism following endothelial cell activation is the release of angiopoietin-2 (Ang-2), which subsequently antagonizes the binding of Ang-1 to the Tie-2 receptor, thus sensitizing the endothelial cells to pro-angiogenic and/or pro-inflammatory stimuli. Based on the observation that hypertension in mice reduces the abundance of Ang-2 stored in arterial endothelial cells, this study was aimed at testing the hypothesis that an increase in wall stress (WS) or stretch-a hallmark of hypertension-is sufficient to release Ang-2 from endothelial cells.

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