Nitric oxide enhances the anti-inflammatory and anti-atherogenic activity of atorvastatin in a mouse model of accelerated atherosclerosis | Zendy

Stefania Momi | Zendy; Angela Monopoli | Zendy; Paolo Alberti | Zendy; Emanuela Falcinelli | Zendy; Teresa Corazzi | Zendy; Valentina Conti | Zendy; Daniela Miglietta | Zendy; Ennio Ongini | Zendy; Pietro Minuz | Zendy; Paolo Gresele | Zendy

Open Access

Nitric oxide enhances the anti-inflammatory and anti-atherogenic activity of atorvastatin in a mouse model of accelerated atherosclerosis

Author(s) -

Stefania Momi,

Angela Monopoli,

Paolo Alberti,

Emanuela Falcinelli,

Teresa Corazzi,

Valentina Conti,

Daniela Miglietta,

Ennio Ongini,

Pietro Minuz,

Paolo Gresele

Publication year - 2012

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvs100

Subject(s) - atorvastatin , nitric oxide , inflammation , lipid peroxidation , endothelial dysfunction , pharmacology , animal model , anti inflammatory , medicine , oxidative stress , chemistry

The aim of the present study was to assess whether the addition of a nitric oxide (NO)-donating moiety to atorvastatin enhances anti-inflammatory and anti-atherogenic effects in an animal model of endothelial dysfunction, systemic peroxidation and inflammation, and accelerated atherosclerosis.

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