Open AccessRNA-binding protein RBM24 is required for sarcomere assembly and heart contractility
Author(s) -
Kar Lai Poon,
Kar Tong Tan,
Yang Wei,
Chee Peng Ng,
Alan Colman,
Vladimir Korzh,
Xiu Qin Xu
Publication year - 2012
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvs095
Subject(s) - sarcomere , contractility , rna , rna binding protein , microbiology and biotechnology , chemistry , cardiology , biology , myocyte , medicine , biochemistry , gene
The factors responsible for cardiomyopathy are not fully understood. Our studies of the transcriptome of human embryonic stem cell-derived cardiomyocytes identified novel genes up-regulated during cardiac differentiation, including RBM24. We therefore studied how its deficiency affected heart development.
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