Open AccessProarrhythmia in KCNJ2-linked short QT syndrome: insights from modelling
Author(s) -
Ismail Adeniran,
Aziza El Harchi,
Jules C. Hancox,
Henggui Zhang
Publication year - 2012
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvs082
Subject(s) - proarrhythmia , long qt syndrome , medicine , cardiology , qt interval
One form of the short QT syndrome (SQT3) has been linked to the D172N gain-in-function mutation to Kir2.1, which preferentially increases outward current through channels responsible for inward rectifier K(+) current (I(K1)). This study investigated mechanisms by which the Kir2.1 D172N mutation facilitates and perpetuates ventricular arrhythmias.
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