Connexin43 ablation in foetal atrial myocytes decreases electrical coupling, partner connexins, and sodium current | Zendy

Thomas Desplantez | Zendy; Megan L. McCain | Zendy; Philippe Beauchamp | Zendy; Ghislaine Rigoli | Zendy; Barbara RothenRutishauser | Zendy; Kevin Kit Parker | Zendy; André G. Kléber | Zendy

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Connexin43 ablation in foetal atrial myocytes decreases electrical coupling, partner connexins, and sodium current

Author(s) -

Thomas Desplantez,

Megan L. McCain,

Philippe Beauchamp,

Ghislaine Rigoli,

Barbara RothenRutishauser,

Kevin Kit Parker,

André G. Kléber

Publication year - 2012

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvs025

Subject(s) - atrial myocytes , medicine , atrial fibrillation , ablation , myocyte , coupling (piping) , gap junction , connexin , cardiology , electrophysiology , endocrinology , biology , chemistry , microbiology and biotechnology , intracellular , materials science , metallurgy

Remodelling and regional gradients in expression of connexins (Cx) are thought to contribute to atrial electrical dysfunction and atrial fibrillation. We assessed the effect of interaction between Cx43, Cx40, and Cx45 on atrial cell-to-cell coupling and inward Na current (I(Na)) in engineered pairs of atrial myocytes derived from wild-type mice (Cx43(+/+)) and mice with genetic ablation of Cx43 (Cx43(-/-)).

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