VEGF-induced endothelial cell migration requires urokinase receptor (uPAR)-dependent integrin redistribution | Zendy

Revu Ann Alexander | Zendy; Gerald W. Prager | Zendy; Judit MihalyBison | Zendy; Pavel Uhrín | Zendy; Stefan Sunzenauer | Zendy; Bernd R. Binder | Zendy; Gerhard J. Schütz | Zendy; Michael Freissmuth | Zendy; Johannes M. Breuss | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

VEGF-induced endothelial cell migration requires urokinase receptor (uPAR)-dependent integrin redistribution

Author(s) -

Revu Ann Alexander,

Gerald W. Prager,

Judit MihalyBison,

Pavel Uhrín,

Stefan Sunzenauer,

Bernd R. Binder,

Gerhard J. Schütz,

Michael Freissmuth,

Johannes M. Breuss

Publication year - 2012

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvs017

Subject(s) - urokinase receptor , integrin , microbiology and biotechnology , angiogenesis , cell migration , endothelial stem cell , biology , chemistry , cancer research , receptor , cell , biochemistry , in vitro

Vascular endothelial growth factor (VEGF)-initiated angiogenesis requires coordinated proteolytic degradation of extracellular matrix provided by the urokinase plasminogen activator/urokinase receptor (uPA/uPAR) system and regulation of cell migration provided by integrin-matrix interaction. In this study, we investigated the mechanisms underlying the uPAR-dependent modulation of VEGF-induced endothelial migration.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research