Reduction in IL-33 expression exaggerates ischaemia/reperfusion-induced myocardial injury in mice with diabetes mellitus | Zendy

Tao Rui | Zendy; Jinchao Zhang | Zendy; Xuemei Xu | Zendy; Yongwei Yao | Zendy; Raymond Kao | Zendy; Claudio M. Martin | Zendy

Open Access

Reduction in IL-33 expression exaggerates ischaemia/reperfusion-induced myocardial injury in mice with diabetes mellitus

Author(s) -

Tao Rui,

Jinchao Zhang,

Xuemei Xu,

Yongwei Yao,

Raymond Kao,

Claudio M. Martin

Publication year - 2012

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvs015

Subject(s) - medicine , diabetes mellitus , cardiology , ischemia , reperfusion injury , myocardial infarction , endocrinology

The underlying mechanism(s) of vulnerability of the diabetic myocardium to ischaemia/reperfusion (I/R)-induced injury is not fully understood. Interleukin-33 (IL-33) has been reported showing the beneficial effect to the myocardium on I/R injury. The aims of this study were to test whether diabetes mellitus (DM) affects myocardial levels of IL-33 and to examine whether reduction in IL-33 is responsible for exaggerated I/R injury in the diabetic myocardium.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research