Sphingosine-1-phosphate induces contraction of valvular interstitial cells from porcine aortic valves | Zendy

Wolfgang Witt | Zendy; Anett Jannasch | Zendy; Daniela Burkhard | Zendy; Torsten Christ | Zendy; Ursula Ravens | Zendy; Coy Brunßen | Zendy; Anja Leuner | Zendy; Henning Morawietz | Zendy; Klaus Matschke | Zendy; Thomas Waldow | Zendy

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Sphingosine-1-phosphate induces contraction of valvular interstitial cells from porcine aortic valves

Author(s) -

Wolfgang Witt,

Anett Jannasch,

Daniela Burkhard,

Torsten Christ,

Ursula Ravens,

Coy Brunßen,

Anja Leuner,

Henning Morawietz,

Klaus Matschke,

Thomas Waldow

Publication year - 2012

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvs002

Subject(s) - rhoa , sphingosine 1 phosphate , aortic valve , contraction (grammar) , microbiology and biotechnology , medicine , interstitial cell , biology , sphingosine , chemistry , endocrinology , receptor , signal transduction

Sphingosine-1-phosphate (S1P) has emerged as a potent bioactive lipid with multiple functions in cardiovascular pathophysiology. Potential roles of S1P in heart valve diseases and expression of relevant receptors (S1P1, S1P2, or S1P3) in valve tissue and in valvular interstitial cells (VICs), the major cell population with essential functions in maintenance of valvular structure, are currently unknown.

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