GATA4 expression is primarily regulated via a miR-26b-dependent post-transcriptional mechanism during cardiac hypertrophy | Zendy

Mingyue Han | Zendy; Zhi Yang | Zendy; Danish Sayed | Zendy; Minzhen He | Zendy; Shumin Gao | Zendy; Lin Lin | Zendy; Seonghun Yoon | Zendy; Maha Abdellatif | Zendy

Open Access

GATA4 expression is primarily regulated via a miR-26b-dependent post-transcriptional mechanism during cardiac hypertrophy

Author(s) -

Mingyue Han,

Zhi Yang,

Danish Sayed,

Minzhen He,

Shumin Gao,

Lin Lin,

Seonghun Yoon,

Maha Abdellatif

Publication year - 2012

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvs001

Subject(s) - gata4 , pressure overload , cardiac myocyte , muscle hypertrophy , myocyte , transcription factor , mechanism (biology) , medicine , biology , cardiac hypertrophy , microrna , microbiology and biotechnology , myocardial hypertrophy , endocrinology , gene , genetics , philosophy , epistemology

GATA4 is a transcription factor that is up-regulated during cardiac hypertrophy and plays a fundamental role in myocyte growth and survival. In this study, we investigate the transcriptional vs. post-transcriptional mechanisms that are involved in regulating GATA4 in the heart during neonatal and pressure overload-induced hypertrophic growth.

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