Pulmonary hypertension in adult Alk1 heterozygous mice due to oxidative stress | Zendy

Mirjana Jerkić | Zendy; Mohammed G. Kabir | Zendy; Adrienne Davies | Zendy; Lisa Yu | Zendy; Brendan A.S. McIntyre | Zendy; Nasir W. Husain | Zendy; Masahiro Enomoto | Zendy; Valentin Sotov | Zendy; Mansoor Husain | Zendy; Mark Henkelman | Zendy; Jaques Belik | Zendy; Michelle Letarte | Zendy

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Pulmonary hypertension in adult Alk1 heterozygous mice due to oxidative stress

Author(s) -

Mirjana Jerkić,

Mohammed G. Kabir,

Adrienne Davies,

Lisa Yu,

Brendan A.S. McIntyre,

Nasir W. Husain,

Masahiro Enomoto,

Valentin Sotov,

Mansoor Husain,

Mark Henkelman,

Jaques Belik,

Michelle Letarte

Publication year - 2011

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvr232

Subject(s) - medicine , endocrinology , pulmonary hypertension , oxidative stress , reactive oxygen species , enos , endothelial dysfunction , lung , nitric oxide , biology , nitric oxide synthase , biochemistry

Mutations in the ALK1 gene, coding for an endothelial-specific receptor of the transforming growth factor-β superfamily, are the underlying cause of hereditary haemorrhagic telangiectasia type 2, but are also associated with familial pulmonary hypertension (PH). We assessed the lung vasculature of mice with a heterozygous deletion of Alk1 (Alk1(+/-)) for disease manifestations and levels of reactive O(2) species (ROS) implicated in both disorders.

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