Open AccessBestrophin is important for the rhythmic but not the tonic contraction in rat mesenteric small arteries
Author(s) -
Torbjoern Broegger,
Jens Christian Brings Jacobsen,
Vibeke Secher Dam,
Donna Briggs Boedtkjer,
Henrik Kold-Petersen,
Finn Skou Pedersen,
Christian Aalkjær,
Vladimir V. Matchkov
Publication year - 2011
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvr111
Subject(s) - vasomotion , mesenteric arteries , vascular smooth muscle , endocrinology , medicine , anatomy , biology , chemistry , vasodilation , artery , smooth muscle
We have previously characterized a cGMP-dependent Ca(2+)-activated Cl(-) current in vascular smooth muscle cells (SMCs) and have shown its dependence on bestrophin-3 expression. We hypothesize that this current is important for synchronization of SMCs in the vascular wall. In the present study, we aimed to test this hypothesis by transfecting rat mesenteric small arteries in vivo with siRNA specifically targeting bestrophin-3.