Open AccessEffect of S-adenosylmethionine on neointimal formation after balloon injury in obese diabetic rats
Author(s) -
Soo Lim,
Min Kyong Moon,
Hayley Shin,
Tae Hyuk Kim,
Bong Jun Cho,
Min Kim,
Ho Seon Park,
Sung Hee Choi,
Seong Hee Ko,
Myung Hee Chung,
In Kyu Lee,
Hak Chul Jang,
Young–Bum Kim,
Kyong Soo Park
Publication year - 2011
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvr009
Subject(s) - neointima , endocrinology , medicine , vascular smooth muscle , restenosis , adiponectin , apoptosis , chemistry , diabetes mellitus , insulin resistance , biochemistry , smooth muscle , stent
The association between hyperhomocysteinaemia and cardiovascular disease has been attributed to low levels of S-adenosylmethionine (SAM), a metabolic intermediate of homocysteine. However, the role of SAM in the development of restenosis has not been explored. Therefore, we investigated the effects of SAM on neointimal formation after balloon injury in obese diabetic rats and cultured cells.