Open AccessMutations in sodium channel β-subunit SCN3B are associated with early-onset lone atrial fibrillation
Author(s) -
Morten Olesen,
Thomas Jespersen,
Jonas B. Nielsen,
Bo Liang,
Daniél Vega Møller,
Paula L. Hedley,
Michael Christiansen,
András Varró,
Søren-Peter Olesen,
Stig Haunsø,
Nicole Schmitt,
Jesper Hastrup Svendsen
Publication year - 2010
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvq348
Subject(s) - genetics , sodium channel , mutation , gene , biology , allele , coding region , medicine , sodium , chemistry , organic chemistry
Atrial fibrillation (AF) is the most frequent arrhythmia. Screening of SCN5A-the gene encoding the α-subunit of the cardiac sodium channel-has indicated that disturbances of the sodium current may play a central role in the mechanism of lone AF. We tested the hypothesis that lone AF in young patients is associated with genetic mutations in SCN3B and SCN4B, the genes encoding the two β-subunits of the cardiac sodium channel.