Egr-1 deficiency in bone marrow-derived cells reduces atherosclerotic lesion formation in a hyperlipidaemic mouse model | Zendy

Claudia Albrecht | Zendy; Michael Preusch | Zendy; Götz Hofmann | Zendy; Samuel Morris-Rosenfeld | Zendy; Erwin Blessing | Zendy; Michael E. Rosenfeld | Zendy; Hugo A. Katus | Zendy; Florian Bea | Zendy

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Egr-1 deficiency in bone marrow-derived cells reduces atherosclerotic lesion formation in a hyperlipidaemic mouse model

Author(s) -

Claudia Albrecht,

Michael Preusch,

Götz Hofmann,

Samuel Morris-Rosenfeld,

Erwin Blessing,

Michael E. Rosenfeld,

Hugo A. Katus,

Florian Bea

Publication year - 2010

Publication title -

cardiovascular research

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvq032

Subject(s) - bone marrow , medicine , lesion , cardiology , pathology , endocrinology

Early growth response gene-1 (Egr-1) regulates the expression of genes important to cardiovascular disease. Within atherosclerotic lesions, Egr-1 is expressed in smooth muscle cells, endothelial cells, and macrophages. Since macrophages play a pivotal role in atherosclerotic lesion initiation and progression, this study investigated the effects of Egr-1 deficiency within bone marrow-derived cells on the development of atherosclerosis in a hyperlipidaemic mouse model.

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