Molecular and functional effects of organismal ageing on smooth muscle cells derived from bone marrow mesenchymal stem cells | Zendy

Juhee Han | Zendy; Jin Yu Liu | Zendy; Daniel D. Swartz | Zendy; Stelios T. Andreadis | Zendy

Open Access

Molecular and functional effects of organismal ageing on smooth muscle cells derived from bone marrow mesenchymal stem cells

Author(s) -

Juhee Han,

Jin Yu Liu,

Daniel D. Swartz,

Stelios T. Andreadis

Publication year - 2010

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvq024

Subject(s) - biology , mesenchymal stem cell , vascular smooth muscle , tropoelastin , desmin , progenitor cell , contractility , bone marrow , stem cell , microbiology and biotechnology , endocrinology , immunology , extracellular matrix , immunohistochemistry , vimentin , smooth muscle

Bone marrow-derived smooth muscle cells (BM-SMCs) have high potential as an autologous cell source of vascular progenitors but normal cell function and turnover frequency may decline with age. In this study we set out to study the effects of organismal ageing on the molecular and functional properties of BM-SMCs.

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