OxLDL stimulates lipoprotein-associated phospholipase A2 expression in THP-1 monocytes via PI3K and p38 MAPK pathways | Zendy

Wenyi Wang | Zendy; Jie Li | Zendy; Yang Ding | Zendy; Wei Xü | Zendy; Ruopeng Zha | Zendy; Yiping Wang | Zendy

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OxLDL stimulates lipoprotein-associated phospholipase A2 expression in THP-1 monocytes via PI3K and p38 MAPK pathways

Author(s) -

Wenyi Wang,

Jie Li,

Yang Ding,

Wei Xü,

Ruopeng Zha,

Yiping Wang

Publication year - 2009

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvp367

Subject(s) - lipoprotein associated phospholipase a2 , phosphatidylinositol , p38 mitogen activated protein kinases , mapk/erk pathway , phospholipase a2 , chemistry , pi3k/akt/mtor pathway , protein kinase a , lipoprotein , phospholipase , kinase , microbiology and biotechnology , foam cell , lipid signaling , monocyte , biochemistry , signal transduction , enzyme , biology , cholesterol , immunology

Lipoprotein-associated phospholipase A2 (lp-PLA2) has been detected in human and rabbit atherosclerotic lesions, where it co-localizes with its substrate, oxidized LDL (oxLDL). Here, we investigated whether oxLDL may exert a regulatory effect on lp-PLA2 expression.

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