Open AccessComplete loss of murine Xin results in a mild cardiac phenotype with altered distribution of intercalated discs
Author(s) -
Julia Otten,
Peter F. M. van der Ven,
Padmanabhan Vakeel,
Stefan Eulitz,
Gregor Kirfel,
Oliver Brandau,
Michael Boesl,
Jan W. Schrickel,
Markus Linhart,
Katrin Hayeß,
Francisco J. Naya,
Hendrik Milting,
Rainer Meyer,
Dieter O. Fürst
Publication year - 2009
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvp345
Subject(s) - phenotype , distribution (mathematics) , medicine , cardiology , biology , genetics , mathematics , gene , mathematical analysis
Xin is a striated muscle-specific F-actin binding protein that has been implicated in cardiomyopathies. In cardiomyocytes, Xin is localized at intercalated discs (IDs). Mice lacking only two of the three Xin isoforms (XinAB(-/-) mice) develop severe cardiac hypertrophy. To further investigate the function of Xin variants in the mammalian heart, we generated XinABC(-/-) mice deficient in all Xin isoforms.
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