Role of AIF in cardiac apoptosis in hypertrophic cardiomyocytes from Dahl salt-sensitive rats | Zendy

Sangita Choudhury | Zendy; Soochan Bae | Zendy; Sheetal R Kumar | Zendy; Qingen Ke | Zendy; Bhargavi Yalamarti | Zendy; Jun H. Choi | Zendy; Lorrie A. Kirshenbaum | Zendy; Peter M. Kang | Zendy

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Role of AIF in cardiac apoptosis in hypertrophic cardiomyocytes from Dahl salt-sensitive rats

Author(s) -

Sangita Choudhury,

Soochan Bae,

Sheetal R Kumar,

Qingen Ke,

Bhargavi Yalamarti,

Jun H. Choi,

Lorrie A. Kirshenbaum,

Peter M. Kang

Publication year - 2009

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvp261

Subject(s) - staurosporine , apoptosis , apoptosis inducing factor , caspase , microbiology and biotechnology , viability assay , programmed cell death , cytochrome c , biology , medicine , endocrinology , signal transduction , biochemistry , protein kinase c

The caspases are thought to be central mediators of the apoptotic program, but recent data indicate that apoptosis may also be mediated by caspase-independent mechanisms such as apoptosis-inducing factor (AIF). The role of AIF-induced apoptosis in heart, however, is currently not well understood. The aim of this study was to investigate the presence of and conditions for AIF-induced cardiac apoptosis in vitro.

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