Attenuated store-operated Ca2+ entry underpins the dual inhibition of nitric oxide and EDHF-type relaxations by iodinated contrast media | Zendy

Silvia Fernandez-Rodriguez | Zendy; D. H. Edwards | Zendy; Ben B. Newton | Zendy; Tudor M. Griffith | Zendy

Open Access

Attenuated store-operated Ca2+ entry underpins the dual inhibition of nitric oxide and EDHF-type relaxations by iodinated contrast media

Author(s) -

Silvia Fernandez-Rodriguez,

D. H. Edwards,

Ben B. Newton,

Tudor M. Griffith

Publication year - 2009

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvp239

Subject(s) - myograph , cyclopiazonic acid , chemistry , nitric oxide , pharmacology , iohexol , biophysics , endothelium , endoplasmic reticulum , iodixanol , vasodilation , biochemistry , medicine , endocrinology , biology , organic chemistry , radiology , renal function , contrast medium

Our objective was to investigate whether alterations in endothelial Ca(2+) homeostasis contribute to the clinical toxicity of iodinated radiographic contrast media (IRCM) by modulating nitric oxide (NO) production and the endothelium-derived hyperpolarizing factor (EDHF) phenomenon.

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