Open AccessNF- B activation is required for adaptive cardiac hypertrophy
Author(s) -
Laura C. Zelarayán,
Anke Renger,
Claudia Noack,
Maria Patapia Zafiriou,
Christina Gehrke,
Roel van der Nagel,
Rainer Dietz,
León J. De Windt,
Martin Bergmann
Publication year - 2009
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvp237
Subject(s) - medicine , endocrinology , muscle hypertrophy , angiotensin ii , pressure overload , fibrosis , angiotensin ii receptor type 1 , in vivo , stimulation , chemistry , biology , cardiac hypertrophy , blood pressure , microbiology and biotechnology
We have previously shown that cardiac-specific inhibition of NF-kappaB attenuates angiotensin II (AngII)-induced left ventricular (LV) hypertrophy in vivo. We now tested whether NF-kappaB inhibition is able to block LV remodelling upon chronic pressure overload and chronic AngII stimulation.
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