A potential link between peroxisome proliferator-activated receptor signalling and the pathogenesis of arrhythmogenic right ventricular cardiomyopathy | Zendy

Fatima Djouadi | Zendy; Yves Lecarpentier | Zendy; JeanLouis Hébert | Zendy; Philippe Charron | Zendy; Jean Bastin | Zendy; Catherine Coirault | Zendy

Open Access

A potential link between peroxisome proliferator-activated receptor signalling and the pathogenesis of arrhythmogenic right ventricular cardiomyopathy

Author(s) -

Fatima Djouadi,

Yves Lecarpentier,

JeanLouis Hébert,

Philippe Charron,

Jean Bastin,

Catherine Coirault

Publication year - 2009

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvp183

Subject(s) - ventricle , peroxisome , medicine , peroxisome proliferator activated receptor , pathogenesis , cardiomyopathy , peroxisome proliferator , receptor , cardiology , endocrinology , peroxisome proliferator activated receptor gamma , heart failure

Arrhythmogenic right ventricular cardiomyopathy (ARVC) is characterized by major fibro-fatty replacement of the right ventricle (RV). We hypothesized that changes in peroxisome proliferator-activated receptor (PPAR) signalling contributed to myocardium fatty accumulation and contractile dysfunction in ARVC.

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