Open AccessTargeted G-protein inhibition as a novel approach to decrease vagal atrial fibrillation by selective parasympathetic attenuation
Author(s) -
Gary L. Aistrup,
Roger Villuendas,
Jason Ng,
Annette Gilchrist,
Thomas W. Lynch,
David Gordon,
Ivan Cokic,
Steven Mottl,
Rui Zhou,
David A. Dean,
J. Andrew Wasserstrom,
Jeffrey J. Goldberger,
Alan H. Kadish,
Rishi Arora
Publication year - 2009
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvp148
Subject(s) - medicine , heterotrimeric g protein , atrial fibrillation , endocrinology , carbachol , g protein , parasympathetic nervous system , stimulation , cholinergic , denervation , autonomic nervous system , receptor , heart rate , blood pressure
The parasympathetic nervous system is thought to play a key role in atrial fibrillation (AF). Since parasympathetic signalling is primarily mediated by the heterotrimeric G-protein, Galpha(i)betagamma, we hypothesized that targeted inhibition of Galpha(i) interactions in the posterior left atrium (PLA) would modify the substrate for vagal AF.
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