Statins normalize vascular lysyl oxidase down-regulation induced by proatherogenic risk factors | Zendy

Cristina Rodrı́guez | Zendy; Javier F. Alcudia | Zendy; José MartínezGonzález | Zendy; Anna Guadall | Zendy; Berta Raposo | Zendy; Sonia Sánchez-Gómez | Zendy; Lina Badimón | Zendy

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Statins normalize vascular lysyl oxidase down-regulation induced by proatherogenic risk factors

Author(s) -

Cristina Rodrı́guez,

Javier F. Alcudia,

José MartínezGonzález,

Anna Guadall,

Berta Raposo,

Sonia Sánchez-Gómez,

Lina Badimón

Publication year - 2009

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvp136

Subject(s) - lysyl oxidase , proinflammatory cytokine , endothelial dysfunction , medicine , extracellular matrix , endocrinology , inflammation , pharmacology , chemistry , biochemistry

Statins are lipid-lowering drugs widely used in the management of vascular diseases. Clinical and experimental evidence suggest that statins improve endothelial function by both cholesterol-lowering-dependent and -independent mechanisms. We have previously shown that endothelial dysfunction induced by risk factors and proinflammatory cytokines is associated with down-regulation of lysyl oxidase (LOX), a key enzyme modulating extracellular matrix maturation and vascular integrity. Our aim was to analyse whether statins could normalize LOX expression impaired by proatherogenic risk factors.

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