Open AccessPeroxisome proliferator-activated receptor β stimulation induces rapid cardiac growth and angiogenesis via direct activation of calcineurin
Author(s) -
Nicole Wagner,
Chantal Jehl-Piétri,
Pascal Lopez,
Joseph Murdaca,
Christian Giordano,
Chantal Schwartz,
Pierre Gou,
Stéphane N. Hatem,
Paul A. Grimaldi,
KayDietrich Wagner
Publication year - 2009
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvp106
Subject(s) - peroxisome proliferator activated receptor , endocrinology , medicine , downregulation and upregulation , stimulation , receptor , calcineurin , biology , ppar agonist , chemistry , transplantation , biochemistry , gene
Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors. PPARbeta agonists were suggested as potential drugs for the treatment of metabolic syndrome, but effects of PPARbeta activation on cardiac growth and vascularization are unknown. Thus, we investigated the consequences of pharmacological PPARbeta activation on the heart and the underlying molecular mechanisms.
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