The targeting of cyclophilin D by RNAi as a novel cardioprotective therapy: evidence from two-photon imaging | Zendy

Masashi Kato | Zendy; Masaharu Akao | Zendy; Madoka Matsumoto-Ida | Zendy; Takeru Makiyama | Zendy; Moritake Iguchi | Zendy; Toshihiro Takeda | Zendy; Shigeomi Shimizu | Zendy; Toru Kita | Zendy

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The targeting of cyclophilin D by RNAi as a novel cardioprotective therapy: evidence from two-photon imaging

Author(s) -

Masashi Kato,

Masaharu Akao,

Madoka Matsumoto-Ida,

Takeru Makiyama,

Moritake Iguchi,

Toshihiro Takeda,

Shigeomi Shimizu,

Toru Kita

Publication year - 2009

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvp094

Subject(s) - mitochondrial permeability transition pore , mptp , small interfering rna , gene silencing , microbiology and biotechnology , rna interference , reperfusion injury , mitochondrion , pharmacology , ischemia , biology , chemistry , medicine , cancer research , pathology , programmed cell death , transfection , biochemistry , cardiology , rna , apoptosis , disease , parkinson's disease , gene

An opening of the mitochondrial permeability transition pore (MPTP), which leads to the loss of mitochondrial membrane potential (DeltaPsi(m)), is the earliest event that commits cells to death, and this process is potentially a prime target for therapeutic intervention against myocardial ischaemia/reperfusion. We aimed to investigate the protective effects of RNA interference (RNAi)-mediated gene silencing of cyclophilin D (CypD), one of the putative components of the MPTP, against myocardial ischaemia/reperfusion using two-photon laser scanning microscopy.

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