Open AccessSalicylates dilate blood vessels through inhibiting PYK2-mediated RhoA/Rho-kinase activation
Author(s) -
Zhekang Ying,
Fernanda R. Giachini,
Rita C. Tostes,
R. Clinton Webb
Publication year - 2009
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvp084
Subject(s) - rhoa , rho associated protein kinase , myosin light chain phosphatase , pharmacology , vasodilation , chemistry , fasudil , phosphorylation , kinase , sodium salicylate , medicine , endocrinology , biochemistry , signal transduction
Compared with other non-steroid anti-inflammatory drugs (NSAIDs), aspirin is not correlated to hypertension. It has been shown that aspirin has unique vasodilator action in vivo, offering an explanation for the unique blood pressure effect of aspirin. In the present study, we investigate the mechanism whereby salicylates (aspirin and sodium salicylate) dilate blood vessels.
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