Open AccessBerberine prevents hyperglycemia-induced endothelial injury and enhances vasodilatation via adenosine monophosphate-activated protein kinase and endothelial nitric oxide synthase
Author(s) -
Yiqun Wang,
Yü Huang,
Karen S.L. Lam,
Yiming Li,
Wing Tak Wong,
Hongying Ye,
Chi-Wai Lau,
Paul M. Vanhoutte,
Aimin Xu
Publication year - 2009
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvp078
Subject(s) - berberine , ampk , endothelial dysfunction , endothelium , enos , nitric oxide , endocrinology , amp activated protein kinase , protein kinase a , medicine , adenosine , vasodilation , nitric oxide synthase , endothelial stem cell , pharmacology , biology , phosphorylation , biochemistry , in vitro
Endothelial dysfunction is a key event that links obesity, diabetes, hypertension, and cardiovascular diseases. The aim of the present study was to examine the protective effect of the alkaloid drug berberine against hyperglycemia-induced cellular injury and endothelial dysfunction.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom