Sulfasalazine induces haem oxygenase-1 via ROS-dependent Nrf2 signalling, leading to control of neointimal hyperplasia | Zendy

JuYoung Kim | Zendy; HyunJai Cho | Zendy; Jung-Ju Sir | Zendy; Baek-Kyung Kim | Zendy; Jin Hur | Zendy; SeockWon Youn | Zendy; HanMo Yang | Zendy; Soo-In Jun | Zendy; Kyung Woo Park | Zendy; Seok-Jae Hwang | Zendy; YooWook Kwon | Zendy; HaeYoung Lee | Zendy; HyunJae Kang | Zendy; ByungHee Oh | Zendy; Young-Bae Park | Zendy; Hyo-Soo Kim | Zendy

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Sulfasalazine induces haem oxygenase-1 via ROS-dependent Nrf2 signalling, leading to control of neointimal hyperplasia

Author(s) -

JuYoung Kim,

HyunJai Cho,

Jung-Ju Sir,

Baek-Kyung Kim,

Jin Hur,

SeockWon Youn,

HanMo Yang,

Soo-In Jun,

Kyung Woo Park,

Seok-Jae Hwang,

YooWook Kwon,

HaeYoung Lee,

HyunJae Kang,

ByungHee Oh,

Young-Bae Park,

Hyo-Soo Kim

Publication year - 2009

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvp072

Subject(s) - neointimal hyperplasia , vascular smooth muscle , reactive oxygen species , cancer research , inflammation , pharmacology , medicine , neointima , chemistry , microbiology and biotechnology , biology , restenosis , smooth muscle , stent

Inflammation, and the subsequent proliferative activity of vascular smooth muscle cells (VSMCs), is one of the major pathophysiological mechanisms associated with neointimal hyperplasia following vascular injury. Although sulfasalazine (SSZ) has been used as an anti-inflammatory and immune-modulatory agent in various inflammatory diseases, its primary targets and therapeutic effects on vascular disease have not yet been determined. We investigated whether SSZ could suppress VSMC growth and prevent neointimal hyperplasia.

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