TGF-β1 inhibits expression and activity of hENT1 in a nitric oxide-dependent manner in human umbilical vein endothelium | Zendy

José Luis Vega | Zendy; Carlos Puebla | Zendy; Rodrigo A. Vásquez | Zendy; Marcelo Farías | Zendy; Julio Alarcón | Zendy; Marçal PastorAnglada | Zendy; Bernardo J. Krause | Zendy; Paola Casanello | Zendy; Luis Sobrevía | Zendy

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TGF-β1 inhibits expression and activity of hENT1 in a nitric oxide-dependent manner in human umbilical vein endothelium

Author(s) -

José Luis Vega,

Carlos Puebla,

Rodrigo A. Vásquez,

Marcelo Farías,

Julio Alarcón,

Marçal PastorAnglada,

Bernardo J. Krause,

Paola Casanello,

Luis Sobrevía

Publication year - 2009

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvp045

Subject(s) - umbilical vein , adenosine , microbiology and biotechnology , endocrinology , medicine , endothelium , biology , nitric oxide , chemistry , biochemistry , in vitro

We studied whether transforming growth factor beta1 (TGF-beta1) modulates human equilibrative nucleoside transporters 1 (hENT1) expression and activity in human umbilical vein endothelial cells (HUVECs). hENT1-mediated adenosine transport and expression are reduced in gestational diabetes and hyperglycaemia, conditions associated with increased synthesis and release of nitric oxide (NO) and TGF-beta1 in this cell type. TGF-beta1 increases NO synthesis via activation of TGF-beta receptor type II (TbetaRII), and NO inhibits hENT1 expression and activity in HUVECs.

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