IL-10 attenuates TNF- -induced NF B pathway activation and cardiomyocyte apoptosis | Zendy

Sanjiv Dhingra | Zendy; Alok Sharma | Zendy; Rakesh C. Arora | Zendy; Ján Slezák | Zendy; Pawan K. Singal | Zendy

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IL-10 attenuates TNF- -induced NF B pathway activation and cardiomyocyte apoptosis

Author(s) -

Sanjiv Dhingra,

Alok Sharma,

Rakesh C. Arora,

Ján Slezák,

Pawan K. Singal

Publication year - 2009

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvp040

Subject(s) - mapk/erk pathway , tumor necrosis factor alpha , p38 mitogen activated protein kinases , phosphorylation , kinase , apoptosis , microbiology and biotechnology , signal transduction , chemistry , protein kinase a , oxidative stress , mitogen activated protein kinase , extracellular , nf κb , cancer research , biology , endocrinology , biochemistry

We have recently reported that tumour necrosis factor-alpha (TNF-alpha) increases oxidative stress and apoptosis in cardiomyocytes by upregulating p38 mitogen-activated protein (MAP) kinase (MAPK) phosphorylation. Interleukin-10 (IL-10) blocked these effects of TNF-alpha by upregulating extracellular signal-regulated kinase 1/2 (ERK 1/2) MAPK phosphorylation. However, the precise site of this IL-10 action is still unknown, and this is investigated in the present study.

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