Open AccessCardioprotection by hypoxia-inducible factor 1 alpha transfection in skeletal muscle is dependent on haem oxygenase activity in mice
Author(s) -
Gábor Czibik,
Julia Sagave,
Vladimir Martinov,
Bushra Ishaq,
Marcus Sohl,
Iren Sefland,
Harald Carlsen,
Filip Farnebo,
Rune Blomhoff,
Guro Valen
Publication year - 2009
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvp035
Subject(s) - skeletal muscle , cardioprotection , transfection , hypoxia inducible factors , hypoxia (environmental) , myocyte , hypoxia inducible factor 1 , chemistry , alpha (finance) , endocrinology , medicine , microbiology and biotechnology , biology , biochemistry , transcription factor , gene , oxygen , ischemia , surgery , organic chemistry , patient satisfaction , construct validity
The present study investigates whether the cardioprotection achieved by gene delivery of hypoxia-inducible factor-1 alpha (HIF-1 alpha) depends on the downstream factor haem oxygenase (HMOX)-1.
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