Effect of uncoupling endothelial nitric oxide synthase on calcium homeostasis in aged porcine endothelial cells | Zendy

Emeline PerrierGroult | Zendy; M.-P. Fournet-Bourguig | Zendy; Emilie Royère | Zendy; Stéphanie Molez | Zendy; Hélène Reure | Zendy; L. Lesage | Zendy; Willy Gosgnach | Zendy; YvesMichel Frapart | Zendy; JeanLuc Boucher | Zendy; Nicole Villeneuve | Zendy; J.-P. Vilaine | Zendy

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Effect of uncoupling endothelial nitric oxide synthase on calcium homeostasis in aged porcine endothelial cells

Author(s) -

Emeline PerrierGroult,

M.-P. Fournet-Bourguig,

Emilie Royère,

Stéphanie Molez,

Hélène Reure,

L. Lesage,

Willy Gosgnach,

YvesMichel Frapart,

JeanLuc Boucher,

Nicole Villeneuve,

J.-P. Vilaine

Publication year - 2009

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvp034

Subject(s) - calcium , nitric oxide synthase , calcium in biology , homeostasis , endothelial nitric oxide synthase , nitric oxide , endothelium , microbiology and biotechnology , nitric oxide synthase type iii , calcium metabolism , endothelial stem cell , intracellular , endocrinology , chemistry , endothelial dysfunction , calcium signaling , atp synthase , medicine , biology , biochemistry , enzyme , in vitro , enos

The requirement of endothelial NO synthase (NOS3) calcium to produce NO is well described, although the effect of NO on intracellular calcium levels [Ca(2+)](i) is still confusing. Therefore, NO and [Ca(2+)](i) cross-talk were studied in parallel in endothelial cells possessing a functional or a dysfunctional NO pathway.

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