Vascular endothelial cell-derived endothelin-1 mediates vascular inflammation and neointima formation following blood flow cessation | Zendy

Dyah Wulan Anggrahini | Zendy; Noriaki Emoto | Zendy; Kazuhiko Nakayama | Zendy; Bambang Widyantoro | Zendy; Suko Adiarto | Zendy; Naoko Iwasa | Zendy; Hidemi aka | Zendy; Yoshiyuki Rikitake | Zendy; Yaz Y. Kisanuki | Zendy; Masashi Yanagisawa | Zendy; Ken–ichi Hirata | Zendy

Open Access

Vascular endothelial cell-derived endothelin-1 mediates vascular inflammation and neointima formation following blood flow cessation

Author(s) -

Dyah Wulan Anggrahini,

Noriaki Emoto,

Kazuhiko Nakayama,

Bambang Widyantoro,

Suko Adiarto,

Naoko Iwasa,

Hidemi aka,

Yoshiyuki Rikitake,

Yaz Y. Kisanuki,

Masashi Yanagisawa,

Ken–ichi Hirata

Publication year - 2009

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvp026

Subject(s) - neointima , inflammation , vascular smooth muscle , vascular remodelling in the embryo , vasoprotective , endothelin 1 , endothelial stem cell , endothelium , vasoconstriction , endothelin receptor , vascular endothelial growth factor c , medicine , vascular endothelial growth factor b , immunology , receptor , biology , vascular endothelial growth factor a , vascular endothelial growth factor , restenosis , nitric oxide , in vitro , biochemistry , smooth muscle , stent , vegf receptors

Although endothelin-1 (ET-1) has been suggested to contribute to the pathogenesis of neointima formation and atherosclerosis, the individual roles of ET-1 derived from certain cell types in this disease remain unclear. In this study, we determined the role of vascular endothelial ET-1 on vascular inflammation and neointima formation using vascular endothelial ET-1-knockout [ET-1(f/f); Tie2-Cre (+)] mice.

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