Native and reconstituted HDL activate Stat3 in ventricular cardiomyocytes via ERK1/2: Role of sphingosine-1-phosphate | Zendy

Miguel A. Frias | Zendy; Richard W. James | Zendy; Christine Gerber-Wicht | Zendy; U. Lang | Zendy

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Native and reconstituted HDL activate Stat3 in ventricular cardiomyocytes via ERK1/2: Role of sphingosine-1-phosphate

Author(s) -

Miguel A. Frias,

Richard W. James,

Christine Gerber-Wicht,

U. Lang

Publication year - 2009

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvp024

Subject(s) - sphingosine 1 phosphate , cholesterol , stat3 , medicine , high density lipoprotein , cardioprotection , chemistry , endocrinology , sphingosine , microbiology and biotechnology , biology , biochemistry , signal transduction , receptor , ischemia

High-density lipoprotein (HDL) has been reported to have cardioprotective properties independent from its cholesterol transport activity. The influence of native HDL and reconstituted HDL (rHDL) on Stat3, the transcription factor playing an important role in myocardium adaptation to stress, was analysed in neonatal rat ventricular cardiomyocytes. We have investigated modulating the composition of rHDL as a means of expanding its function and potential cardioprotective effects.

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