Open AccessMicroRNA expression in response to murine myocardial infarction: miR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue
Author(s) -
Sashwati Roy,
Savita Khanna,
Syed-Rehan A. Hussain,
Sabyasachi Biswas,
Ali Azad,
Cameron Rink,
Surya Gnyawali,
Shani Shilo,
Gerard J. Nuovo,
Chandan K. Sen
Publication year - 2009
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvp015
Subject(s) - tensin , pten , microrna , gene silencing , biology , gene expression , gene expression profiling , in situ hybridization , regulation of gene expression , microbiology and biotechnology , cancer research , gene , signal transduction , pi3k/akt/mtor pathway , genetics
MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression at the post-transcriptional level by either degradation or translational repression of a target mRNA. Encoded in the genome of most eukaryotes, miRNAs have been proposed to regulate specifically up to 90% of human genes through a process known as miRNA-guided RNA silencing. For the first time, we sought to test how myocardial ischaemia-reperfusion (IR) changes miR expression.
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