Open AccessNPC1 repression contributes to lipid accumulation in human macrophages exposed to environmental aryl hydrocarbons
Author(s) -
Normand Podechard,
Eric Le Ferrec,
Amélie Rebillard,
Olivier Fardel,
Valérie Lecureur
Publication year - 2008
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvp007
Subject(s) - npc1 , endosome , sphingolipid , aryl hydrocarbon receptor , lipid droplet , biology , chemistry , sterol regulatory element binding protein , macrophage , microbiology and biotechnology , transfection , biochemistry , cholesterol , transcription factor , receptor , in vitro , sterol , gene
Aryl hydrocarbons (AHs), such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and benzo(a)pyrene (BP), are environmental contaminants promoting the development of atherosclerosis-related cardiovascular diseases. In order to identify molecular mechanisms involved in these effects, we have analysed AH-mediated regulation of the lipid trafficking Niemann-Pick type C1 protein (NPC1) and its contribution to AH-induced macrophage lipid accumulation.
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