Open AccessCardiac chymase converts rat proAngiotensin-12 (PA12) to angiotensin II: effects of PA12 upon cardiac haemodynamics
Author(s) -
Hamish Prosser,
Malcolm E. Forster,
Mark Richards,
C. J. Pemberton
Publication year - 2009
Publication title -
cardiovascular research
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvp003
Subject(s) - chymase , angiotensin ii , renin–angiotensin system , medicine , hemodynamics , endocrinology , biology , blood pressure , enzyme , biochemistry
The aim of this study was to observe the direct physiological and biochemical cardiac effects in response to a newly identified putative component of the renin-angiotensin system, proangiotensin-12 (PA12); and investigate whether PA12 can serve as a substrate for Angiotensin II (AngII) generation.
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