Open AccessA pyrrole–imidazole polyamide targeting transforming growth factor-β1 inhibits restenosis and preserves endothelialization in the injured artery
Author(s) -
EnHui Yao,
Noboru Fukuda,
Takahiro Ueno,
Hiroyuki Matsuda,
Hiroki Nagase,
Yoshiaki Matsumoto,
Hiroshi Sugiyama,
Koichi Matsumoto
Publication year - 2008
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvn355
Subject(s) - neointima , restenosis , ctgf , neointimal hyperplasia , medicine , transforming growth factor , growth factor , receptor , stent
Although the use of drug-eluting stents (DESs) has been shown to limit neointima hyperplasia, currently available DESs may adversely affect re-endothelialization. To evaluate whether a novel gene silencer pyrrole-imidazole (PI) polyamide targeting transforming growth factor (TGF)-beta1 is a candidate agent for the DESs, we examined the effects of PI polyamide targeting the TGF-beta1 promoter on neointimal formation in rat carotid artery after balloon injury.
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