Open AccessRegulation of the ankyrin-B-based targeting pathway following myocardial infarction
Author(s) -
Thomas J. Hund,
Patrick Wright,
Wen Dun,
Jedidiah S. Snyder,
Penelope A. Boyden,
Peter J. Mohler
Publication year - 2008
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvn348
Subject(s) - ankyrin , medicine , ion channel , disease , cardiology , myocardial infarction , microbiology and biotechnology , heart disease , biology , genetics , receptor , gene
Ion channel reorganization is a critical step in the pro-arrhythmogenic remodelling process that occurs in heart disease. Ankyrin-B (AnkB) is required for targeting and stabilizing ion channels, exchangers, and pumps. Despite a wealth of knowledge implicating the importance of AnkB in human cardiovascular physiology, nothing is known regarding the role of AnkB in common forms of acquired human disease.
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