Open AccessJNK1/c-fos inhibits cardiomyocyte TNF- expression via a negative crosstalk with ERK and p38 MAPK in endotoxaemia
Author(s) -
Tianqing Peng,
Tao� Zhang,
Xiangru Lu,
Qingping Feng
Publication year - 2008
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvn336
Subject(s) - crosstalk , mapk/erk pathway , p38 mitogen activated protein kinases , tumor necrosis factor alpha , microbiology and biotechnology , medicine , chemistry , endocrinology , biology , signal transduction , physics , optics
Myocardial tumour necrosis factor-alpha (TNF-alpha) production plays an important role in cardiac dysfunction during sepsis. The aim of this study was to investigate the role of c-Jun NH2-terminal kinases (JNK) signalling in cardiomyocyte TNF-alpha expression during lipopolysaccharide (LPS) stimulation and myocardial function in endotoxaemic mice.
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