Open AccessGenetic analysis of salt-sensitive hypertension in Dahl rats reveals a link between cardiac fibrosis and high cholesterol
Author(s) -
Nora Wendt,
Angela Schulz,
Fatimunnisa Qadri,
Juliane Bolbrinker,
Peter Koßmehl,
K. Winkler,
Monika Stoll,
Roland Vetter,
Reinhold Kreutz
Publication year - 2008
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvn263
Subject(s) - medicine , cholesterol , fibrosis , cardiology , cardiac fibrosis , link (geometry) , endocrinology , biology , computer science , computer network
Previously we confirmed an important role of rat chromosome 19 (RNO19) for salt-sensitive hypertension and target organ damage in male Dahl salt-sensitive rats (SS rats). The aim of this study was to further analyse the basis of left ventricular (LV) fibrosis development in both male and female rats in this model. To this end we utilized a consomic SS-19(SHR) rat strain in which RNO19 was transferred from spontaneously hypertensive rats (SHR) into the susceptible background of SS.
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