Open AccessAdrenomedullin induces lymphangiogenesis and ameliorates secondary lymphoedema
Author(s) -
Dong Jin,
Kazuhiko Harada,
Shunsuke Ohnishi,
Kenich Yamahara,
Kenji Kangawa,
Noritoshi Nagaya
Publication year - 2008
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvn228
Subject(s) - lymphangiogenesis , adrenomedullin , mapk/erk pathway , medicine , angiogenesis , protein kinase a , lymphatic system , endocrinology , cancer research , cyclic adenosine monophosphate , kinase , adenosine , vasodilation , pharmacology , microbiology and biotechnology , biology , pathology , receptor , metastasis , cancer
Adrenomedullin (AM) is a multifunctional peptide hormone that plays a significant role in vasodilation and angiogenesis. Lymphoedema is a common but refractory disorder that is difficult to be treated with conventional therapy. We therefore investigated whether AM promotes lymphangiogenesis and improves lymphoedema.