Open AccessDepletion of zebrafish essential and regulatory myosin light chains reduces cardiac function through distinct mechanisms
Author(s) -
Zhenyue Chen,
Wei Huang,
Tillman Dahme,
Wolfgang Rottbauer,
Michael J. Ackerman,
Xiaolei Xu
Publication year - 2008
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvn073
Subject(s) - zebrafish , immunoglobulin light chain , myosin , myosin light chain kinase , myh7 , function (biology) , microbiology and biotechnology , biology , vertebrate , myh6 , gene , genetics , antibody
Mutations in the essential myosin light chain (ELC) and regulatory myosin light chain (RLC) genes have been linked to sarcomeric hypertrophic cardiomyopathies in humans; however, the specific functions of the different myosin light chains during cardiogenesis in a vertebrate animal are not well understood.
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