Open AccessBlood flow-dependent arterial remodelling is facilitated by inflammation but directed by vascular tone
Author(s) -
Erik N.T.P. Bakker,
Hanke L. Matlung,
Peter I. Bonta,
Carlie J.M. de Vries,
Nico van Rooijen,
Ed VanBavel
Publication year - 2008
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvn050
Subject(s) - vascular remodelling in the embryo , blood flow , inflammation , vasodilation , pathology , immunostaining , in vivo , biology , medicine , immunohistochemistry , microbiology and biotechnology
Altered blood flow affects vascular tone, attracts inflammatory cells, and leads to microvascular remodelling. We tested the hypothesis that inflammation facilitates the remodelling response, but that vascular tone determines its direction (inward or outward).
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