Besides adhesion: new perspectives of integrin functions in angiogenesis | Zendy

Guido Serini | Zendy; Lucia Napione | Zendy; Marco Arese | Zendy; Federico Bussolino | Zendy

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Besides adhesion: new perspectives of integrin functions in angiogenesis

Author(s) -

Guido Serini,

Lucia Napione,

Marco Arese,

Federico Bussolino

Publication year - 2008

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvn045

Subject(s) - integrin , angiogenesis , microbiology and biotechnology , semaphorin , autocrine signalling , extracellular matrix , neuropilin , cell adhesion molecule , cell adhesion , thrombospondin 1 , biology , plexin , paracrine signalling , receptor tyrosine kinase , neuropilin 1 , receptor , signal transduction , cancer research , vascular endothelial growth factor , cell , biochemistry , vegf receptors

During angiogenic remodelling in embryo and adult life, endothelial cells lining blood vessel walls dynamically modify their integrin-mediated adhesive contacts with the surrounding extracellular matrix. However, besides regulating cell adhesion and migration, integrins dynamically participate in a network with soluble molecules and their receptors. Angiogenesis is characterized by opposing autocrine and paracrine loops of growth factors and semaphorins that regulate the activation of integrins on the endothelial surface through tyrosine kinase receptors (TKR) and the neuropilin/plexin system. Moreover, pro- and anti-angiogenic factors can directly bind integrins and regulate endothelial cell behaviour. This review summarizes the recent progress in understanding the reciprocal interactions between integrins, TKR, and semaphorin receptors.

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