Rapamycin modulates the eNOS vs. shear stress relationship | Zendy

Caroline Cheng | Zendy; Dennie Tempel | Zendy; Angela E. Oostlander | Zendy; Frank Helderman | Zendy; Frank Gijsen | Zendy; Jolanda J. Wentzel | Zendy; Rien van Haperen | Zendy; David B. Haitsma | Zendy; Patrick W. Serruys | Zendy; Anton F. W. van der Steen | Zendy; Rini de Crom | Zendy; Rob Krams | Zendy

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Rapamycin modulates the eNOS vs. shear stress relationship

Author(s) -

Caroline Cheng,

Dennie Tempel,

Angela E. Oostlander,

Frank Helderman,

Frank Gijsen,

Jolanda J. Wentzel,

Rien van Haperen,

David B. Haitsma,

Patrick W. Serruys,

Anton F. W. van der Steen,

Rini de Crom,

Rob Krams

Publication year - 2007

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvm103

Subject(s) - enos , endocrinology , medicine , nitric oxide synthase type iii , endothelial nitric oxide synthase , vasodilation , nitric oxide synthase , chemistry , nitric oxide , biology

Studies in animals and patients indicate that rapamycin affects vasodilatation differently in outer and inner curvatures of blood vessels. We evaluated in this study whether rapamycin affects endothelial nitric oxide synthase (eNOS) responsiveness to shear stress under normo- and hypercholesteraemic conditions to explain these findings.

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