Disruption of phospholipase C 1 signalling attenuates cardiac tumor necrosis factor- expression and improves myocardial function during endotoxemia | Zendy

Tianqing Peng | Zendy; Enhui Shen | Zendy; Jiaxin Fan | Zendy; Yanli Zhang | Zendy; J. Malcolm O. Arnold | Zendy; Qingping Feng | Zendy

Open Access

Disruption of phospholipase C 1 signalling attenuates cardiac tumor necrosis factor- expression and improves myocardial function during endotoxemia

Author(s) -

Tianqing Peng,

Enhui Shen,

Jiaxin Fan,

Yanli Zhang,

J. Malcolm O. Arnold,

Qingping Feng

Publication year - 2007

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvm100

Subject(s) - tumor necrosis factor alpha , phospholipase c , biology , endocrinology , signal transduction , medicine , gene knockdown , cancer research , immunology , microbiology and biotechnology , cell culture , genetics

Lipopolysaccharide (LPS) induces tumor necrosis factor-alpha (TNF-alpha) expression in cardiomyocytes, which contributes to myocardial dysfunction during sepsis. The purpose of this study was to investigate the role of phosphatidylinositol (PI) phospholipase Cgamma1 (PLCgamma1) in cardiac TNF-alpha expression, and myocardial dysfunction during endotoxemia.

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